Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.
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ABSTRACT:
SUBMITTER: Abu Hamdeh S
PROVIDER: S-EPMC5931620 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue.
Abu Hamdeh Sami S Shevchenko Ganna G Mi Jia J Musunuri Sravani S Bergquist Jonas J Marklund Niklas N
Scientific reports 20180501 1
The early molecular response to severe traumatic brain injury (TBI) was evaluated using biopsies of structurally normal-appearing cortex, obtained at location for intracranial pressure (ICP) monitoring, from 16 severe TBI patients. Mass spectrometry (MS; label free and stable isotope dimethyl labeling) quantitation proteomics showed a strikingly different molecular pattern in TBI in comparison to cortical biopsies from 11 idiopathic normal pressure hydrocephalus patients. Diffuse TBI showed incr ...[more]
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