Proteomic changes in traumatic brain injury: experimental approaches.
Ontology highlight
ABSTRACT:
SUBMITTER: Sowers JL
PROVIDER: S-EPMC6221404 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Publications
Proteomic changes in traumatic brain injury: experimental approaches.
Sowers James L JL Wu Ping P Zhang Kangling K DeWitt Douglas S DS Prough Donald S DS
Current opinion in neurology 20181201 6
<h4>Purpose of review</h4>The underlying mechanisms responsible for chronic and progressive neurological damage after traumatic brain injury (TBI) are poorly understood, and therefore, current treatment options are limited. Proteomics is an emerging methodology to study changes to the TBI proteome in both patients and experimental models.<h4>Recent findings</h4>Although experimentally complex, mass spectrometry-based proteomics approaches are converging on a set of common methods. However, these ...[more]
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