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Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids.

ABSTRACT: With microwave irradiation, the submonomer synthesis of dipeptoids on functionalized cellulose can be accelerated with good yields and purity. Optimization provided a library of 96 dipeptoids. From these, 29 compounds were found with an antibacterial activity against MRSA at a concentration of 25 ?M. Large nonpolar residues, such as undecylamine and dehydroabiethylamine, are the key components engendering the observed antibacterial activity of these peptoids.

SUBMITTER: Schneider AC

PROVIDER: S-EPMC5931720 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids.

Schneider Anne C AC Fritz Daniel D Vasquez Joseph K JK Vollrath Sidonie B L SBL Blackwell Helen E HE Bräse Stefan S

ACS combinatorial science 20171107 12

With microwave irradiation, the submonomer synthesis of dipeptoids on functionalized cellulose can be accelerated with good yields and purity. Optimization provided a library of 96 dipeptoids. From these, 29 compounds were found with an antibacterial activity against MRSA at a concentration of 25 μM. Large nonpolar residues, such as undecylamine and dehydroabiethylamine, are the key components engendering the observed antibacterial activity of these peptoids. ...[more]

PMID: 29035557

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