CCDC102B confers risk of low vision and blindness in high myopia.
Ontology highlight
ABSTRACT:
SUBMITTER: Hosoda Y
PROVIDER: S-EPMC5934384 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
CCDC102B confers risk of low vision and blindness in high myopia.
Hosoda Yoshikatsu Y Yoshikawa Munemitsu M Miyake Masahiro M Tabara Yasuharu Y Shimada Noriaki N Zhao Wanting W Oishi Akio A Nakanishi Hideo H Hata Masayuki M Akagi Tadamichi T Ooto Sotaro S Nagaoka Natsuko N Fang Yuxin Y Ohno-Matsui Kyoko K Cheng Ching-Yu CY Saw Seang Mei SM Yamada Ryo R Matsuda Fumihiko F Tsujikawa Akitaka A Yamashiro Kenji K
Nature communications 20180503 1
The incidence of high myopia is increasing worldwide with myopic maculopathy, a complication of myopia, often progressing to blindness. Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10<sup>-12</sup> and P<sub>corr</sub> = 1.61 × 10<sup>-10</sup>). In contrast, this SNP is not significantly associated with myopia itself. The association between rs11873439 and myopic maculopathy is further conf ...[more]
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