Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
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ABSTRACT:
SUBMITTER: Oh SC
PROVIDER: S-EPMC5934392 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Oh Sang Cheul SC Sohn Bo Hwa BH Cheong Jae-Ho JH Kim Sang-Bae SB Lee Jae Eun JE Park Ki Cheong KC Lee Sang Ho SH Park Jong-Lyul JL Park Yun-Yong YY Lee Hyun-Sung HS Jang Hee-Jin HJ Park Eun Sung ES Kim Sang-Cheol SC Heo Jeonghoon J Chu In-Sun IS Jang You-Jin YJ Mok Young-Jae YJ Jung WonKyung W Kim Baek-Hui BH Kim Aeree A Cho Jae Yong JY Lim Jae Yun JY Hayashi Yuki Y Song Shumei S Elimova Elena E Estralla Jeannelyn S JS Lee Jeffrey H JH Bhutani Manoop S MS Lu Yiling Y Liu Wenbin W Lee Jeeyun J Kang Won Ki WK Kim Sung S Noh Sung Hoon SH Mills Gordon B GB Kim Seon-Young SY Ajani Jaffer A JA Lee Ju-Seog JS
Nature communications 20180503 1
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival ...[more]
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