Ontology highlight
ABSTRACT:
SUBMITTER: Vidal E
PROVIDER: S-EPMC5934634 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Vidal Enrique E le Dily François F Quilez Javier J Stadhouders Ralph R Cuartero Yasmina Y Graf Thomas T Marti-Renom Marc A MA Beato Miguel M Filion Guillaume J GJ
Nucleic acids research 20180501 8
The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, Hi-C is subject to systematic biases that can compromise downstream analyses. Several strategies have been proposed to remove those biases, but the issue of abnormal karyotypes received little attention. Many experiments are performed in cancer cell lines, which typically harbo ...[more]