Ontology highlight
ABSTRACT:
SUBMITTER: Dasari S
PROVIDER: S-EPMC5935569 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180209
The aim of this study was to evaluate the therapeutic effects of vitamin K2 (VK2) on castration-resistant prostate cancer (CRPC) and its anti-cancer mechanisms in a pre-clinical study using a VCaP cell line (ATCC<sup>®</sup> CRL-2876™) which was established from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. Our data showed that VK2 significantly inhibited CRPC VCaP cell proliferation in a dose-dependent manner at 48 h treatment in vitro. In addition, VK2 red ...[more]