Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC5936753 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhang Qing Q Xia Yiyuan Y Wang Yongjun Y Shentu Yangping Y Zeng Kuan K Mahaman Yacoubou A R YAR Huang Fang F Wu Mengjuan M Ke Dan D Wang Qun Q Zhang Bin B Liu Rong R Wang Jian-Zhi JZ Ye Keqiang K Wang Xiaochuan X
Frontiers in molecular neuroscience 20180430
Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and is associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation in AD. However, whether CK2 phosphorylates SET and regulates tau pathological phosphorylation in AD remains unclear. Here, we show that CK2 phosphorylating SET at Ser9 induced tau hyperphosphorylation in AD. We found that either Aβ treatment or tau overexpression stimulated CK2 activation leadi ...[more]