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Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents.

ABSTRACT: A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56-12.5?µg?ml-1. Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56?µg?ml-1. Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor.

SUBMITTER: Nalla V

PROVIDER: S-EPMC5936909 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents.

Nalla Viswanadh V Shaikh Aslam A Bapat Sanket S Vyas Renu R Karthikeyan M M Yogeeswari P P Sriram D D Muthukrishnan M M

Royal Society open science 20180404 4

A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56-12.5 µg ml-1. Noticeably, compound 6s was the most potent compound in vitro w ...[more]

PMID: 29765644

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