Role of immune-checkpoint inhibitors in lung cancer.
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ABSTRACT:
SUBMITTER: Jain P
PROVIDER: S-EPMC5937156 | biostudies-literature | 2018 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Role of immune-checkpoint inhibitors in lung cancer.
Jain Prantesh P Jain Chhavi C Velcheti Vamsidhar V
Therapeutic advances in respiratory disease 20180101
Immune checkpoint inhibitors, mainly drugs targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) pathways, represent a remarkable advance in lung cancer treatment. Immune checkpoint inhibitors targeting PD-1 and PD-L1 are approved for the treatment of patients with non-small-cell lung cancer, with impressive clinical activity and durable responses in some patients. This review will summarize the mechanism of action of the ...[more]
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