Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury.

ABSTRACT: Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid mediator, is believed to exert anti-inflammatory and pro-resolution effects. Protectin DX (5?µg/kg) was injected i.v. 8?h after LPS (14?mg/kg) administration, and alveolar fluid clearance was measured in live rats (n?=?8). In primary rat ATII epithelial cells, protectin DX (3.605?×?10^-3?mg/l) was added to the culture medium with LPS for 6?h. Protectin DX improved alveolar fluid clearance (9.65?±?1.60 vs. 15.85?±?1.49, p?

SUBMITTER: Zhuo XJ 

PROVIDER: S-EPMC5938057 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature