Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC5546489 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yan Xuetao X Cheng Xiaoli X Zhou Liwen L He Xianghu X Zheng Wenzhong W Chen Hu H
Oncotarget 20170701 27
This study aimed to investigate the protective effects of dexmedetomidine on lipopolysaccharide (LPS)-induced lung injury in Wistar rats. 24 female Wistar rats were randomly assigned into 3 groups (n = 8): a control group, a LPS-challenged group, and a LPS plus dexmedetomidine group. Inflammation, oxidative stress, Nrf2/Keap1, and Akt signal were determined. The results showed that LPS caused inflammation and oxidative stress via increasing pro-inflammatory cytokines and oxidative products. Dexm ...[more]