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A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma.


ABSTRACT: PURPOSE:To compare the central corneal epithelial thickness (CET), stromal thickness (CST), and total thickness (CCT) in males with and without primary open-angle glaucoma and to determine the factors associated with corneal thickness. METHODS:A case-control study was conducted to evaluate 116 male patients at the Miami Veterans Affair Medical Center. Subjects with available anterior segment optical coherence tomography images (Cirrus HD-OCT, Carl Zeiss Meditec Inc, Dublin, CA) were retrospectively classified into 2 groups by glaucoma status. CET, CST, and CCT measurements between the groups were compared. Associations between thickness and other variables of interest were also evaluated. RESULTS:The 2 groups were similar with respect to race and ethnicity. Mean age of patients in the glaucoma group (70.3 ± 8.9) was higher than in the nonglaucoma group (66.0 ± 11.7), P < 0.03. Individuals who self-identified as black had lower CST (447.8 ± 29.0 ?m) and CCT (503.0 ± 30.5 ?m) compared with whites (CST: 470.0 ± 31.7 ?m; CCT: 525.1 ± 32.4 ?m), P = 0.0001 and P = 0.0002, respectively. In a similar manner, individuals with glaucoma had lower CST (453.4 ± 32.5 ?m) and CCT (507.3 ± 33.8 ?m) than that of those without glaucoma (CST: 465.2 ± 31.2 ?m; CCT: 521.5 ± 31.5 ?m), P = 0.05 and P = 0.02, respectively. CET, CST, and CCT were negatively correlated with the number of antiglaucoma medications (r = -0.2, r = -0.22, and r = -0.25, respectively), P = 0.05 for all. CONCLUSIONS:Individuals with glaucoma have lower CST and CCT measurements compared with individuals without glaucoma. An increased number of glaucoma medications were associated with lower thickness measurements.

SUBMITTER: Batawi H 

PROVIDER: S-EPMC5938118 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma.

Batawi Hatim H   Lollett Ivonne Valentina IV   Maliakal Cima C   Wellik Sarah R SR   Anderson Michael G MG   Feuer William W   Karp Carol L CL   Galor Anat A  

Cornea 20180601 6


<h4>Purpose</h4>To compare the central corneal epithelial thickness (CET), stromal thickness (CST), and total thickness (CCT) in males with and without primary open-angle glaucoma and to determine the factors associated with corneal thickness.<h4>Methods</h4>A case-control study was conducted to evaluate 116 male patients at the Miami Veterans Affair Medical Center. Subjects with available anterior segment optical coherence tomography images (Cirrus HD-OCT, Carl Zeiss Meditec Inc, Dublin, CA) we  ...[more]

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