Effect of Sofosbuvir Plus Daclatasvir in Hepatitis C Virus Genotype-4 Patients: Promising Effect on Liver Fibrosis.

ABSTRACT:

Background/purpose

The effect of sofosbuvir and daclatasvir in treatment of genotype 4 Hepatitis C Virus (HCV) is not well documented. This study investigated the safety and efficacy of sofosbuvir plus daclatasvir with or without ribavirin in treatment of HCV genotype 4 patients. The impact of therapy on liver fibrosis as well as the role of IL18 polymorphism in therapeutic outcome was assessed.

Methods

One hundred HCV genotype 4 patients were categorized into 2 groups. The group 1 comprised treatment naïve patients, with total serum bilirubin ≤ 1.2 mg/10^-1 L, serum albumin ≥ 3.5 g/10^-1 L, INR ≤ 1.2, and platelet count ≥ 150 × 10⁹/L. This group was treated with sofosbuvir plus daclatasvir for 12 weeks. The group 2 included Peg-IFN-α-or sofosb

SUBMITTER: Abdel-Aziz AM 

PROVIDER: S-EPMC5938328 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature