Ontology highlight
ABSTRACT:
SUBMITTER: Bertini E
PROVIDER: S-EPMC5938395 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bertini Edoardo E Merlin Matilde M Gecchele Elisa E Puggia Andrea A Brozzetti Annalisa A Commisso Mauro M Falorni Alberto A Bini Vittorio V Klymyuk Victor V Pezzotti Mario M Avesani Linda L
Frontiers in plant science 20180501
Type-1 diabetes (T1D) is a metabolic disease involving the autoimmune destruction of insulin-producing pancreatic beta cells. It is often diagnosed by the detection of autoantibodies, typically those recognizing insulin itself or the 65-kDa isoform of glutamic acid decarboxylase (GAD65). Oral insulin can be used to induce systemic immunological tolerance and thus prevent or delay the onset of T1D, suggesting that combination treatments with other autoantigens such as GAD65 could be even more suc ...[more]