Ontology highlight
ABSTRACT:
SUBMITTER: Doran TM
PROVIDER: S-EPMC4890052 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cell chemical biology 20160512 5
A major goal in understanding autoimmune diseases is to define the antigens that elicit a self-destructive immune response, but this is a difficult endeavor. In an effort to discover autoantigens associated with type 1 diabetes (T1D), we used epitope surrogate technology that screens combinatorial libraries of synthetic molecules for compounds that could recognize disease-linked autoantibodies and enrich them from serum. Autoantibodies from one patient revealed a highly phosphorylated form of pe ...[more]