Ontology highlight
ABSTRACT:
SUBMITTER: Sehrawat A
PROVIDER: S-EPMC5939079 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sehrawat Archana A Gao Lina L Wang Yuliang Y Bankhead Armand A McWeeney Shannon K SK King Carly J CJ Schwartzman Jacob J Urrutia Joshua J Bisson William H WH Coleman Daniel J DJ Joshi Sunil K SK Kim Dae-Hwan DH Sampson David A DA Weinmann Sheila S Kallakury Bhaskar V S BVS Berry Deborah L DL Haque Reina R Van Den Eeden Stephen K SK Sharma Sunil S Bearss Jared J Beer Tomasz M TM Thomas George V GV Heiser Laura M LM Alumkal Joshi J JJ
Proceedings of the National Academy of Sciences of the United States of America 20180326 18
Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new treatments targeting molecular pathways enriched in lethal prostate cancer. Lysine-specific demethylase 1 (LSD1) is a histone demethylase and an important regulator of gene expression ...[more]