Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama A
PROVIDER: S-EPMC2423124 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Yokoyama Atsushi A Takezawa Shinichiro S Schüle Roland R Kitagawa Hirochika H Kato Shigeaki S
Molecular and cellular biology 20080407 12
TLX is an orphan nuclear receptor (also called NR2E1) that regulates the expression of target genes by functioning as a constitutive transrepressor. The physiological significance of TLX in the cytodifferentiation of neural cells in the brain is known. However, the corepressors supporting the transrepressive function of TLX have yet to be identified. In this report, Y79 retinoblastoma cells were subjected to biochemical techniques to purify proteins that interact with TLX, and we identified LSD1 ...[more]