Ontology highlight
ABSTRACT:
SUBMITTER: Han J
PROVIDER: S-EPMC5939577 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Han Julianna J Perez Jasmine T JT Chen Cindy C Li Yan Y Benitez Asiel A Kandasamy Matheswaran M Lee Yoontae Y Andrade Jorge J tenOever Benjamin B Manicassamy Balaji B
Cell reports 20180401 2
The emergence of influenza A viruses (IAVs) from zoonotic reservoirs poses a great threat to human health. As seasonal vaccines are ineffective against zoonotic strains, and newly transmitted viruses can quickly acquire drug resistance, there remains a need for host-directed therapeutics against IAVs. Here, we performed a genome-scale CRISPR/Cas9 knockout screen in human lung epithelial cells with a human isolate of an avian H5N1 strain. Several genes involved in sialic acid biosynthesis and rel ...[more]