Ontology highlight
ABSTRACT:
SUBMITTER: Sedlmayer F
PROVIDER: S-EPMC5940823 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sedlmayer Ferdinand F Hell Dennis D Müller Marius M Ausländer David D Fussenegger Martin M
Nature communications 20180508 1
Quorum sensing is a promising target for next-generation anti-infectives designed to address evolving bacterial drug resistance. The autoinducer-2 (AI-2) is a key quorum-sensing signal molecule which regulates bacterial group behaviors and is recognized by many Gram-negative and Gram-positive bacteria. Here we report a synthetic mammalian cell-based microbial-control device that detects microbial chemotactic formyl peptides through a formyl peptide sensor (FPS) and responds by releasing AI-2. Th ...[more]