Ontology highlight
ABSTRACT:
SUBMITTER: Le Magnen C
PROVIDER: S-EPMC5942183 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Le Magnen Clémentine C Shen Michael M MM Shen Michael M MM Abate-Shen Cory C
Annual review of cancer biology 20171201
Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticity by changing their identity, either by dedifferentiation to a progenitor-like state or by transdifferentiation to an alternative differentiated cell type. Such cellular plasticity can be triggered by physiological or oncogenic stress, or it can be experimenta ...[more]