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Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [miRNA]

ABSTRACT: We report a comprehensive molecular analysis of 22 cases of SCC

ORGANISM(S): Homo sapiens

PROVIDER: GSE145259 | GEO | 2020/10/01

REPOSITORIES: GEO

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Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [RNA]

Project description:We report a comprehensive molecular analysis of 22 cases of SCC

2020-10-01 | GSE145260 | GEO

Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer.

Project description:We report a comprehensive molecular analysis of 34 cases of small cell carcinoma (SCC) and 84 cases of conventional urothelial carcinoma (UC), with The Cancer Genome Atlas cohort of 408 conventional UC bladder cancers used as the reference. SCCs showed mutational landscapes characterized by nearly uniform inactivation of TP53 and were dominated by Sanger mutation signature 3 associated with loss of BRCA1/2 function. SCCs were characterized by downregulation of luminal and basal markers and were referred to as double-negative. Transcriptome analyses indicated that SCCs displayed lineage plasticity driven by a urothelial-to-neural phenotypic switch with a dysregulated epithelial-to-mesenchymal transition network. SCCs were depleted of immune cells, and expressed high levels of the immune checkpoint receptor, adenosine receptor A2A (ADORA2A), which is a potent inhibitor of immune infiltration. Our observations have important implications for the prognostication and development of more effective therapies for this lethal bladder cancer variant.

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Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-01 | GSE145261 | GEO

Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer

Project description:Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer

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Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [RNA]

Project description:Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [RNA]

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Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [miRNA]

Project description:Urothelial-to-Neural Lineage Plasticity Drives Progression to Small Cell Bladder Cancer [miRNA]

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FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation.

Project description:Cancers arising from the bladder urothelium often exhibit lineage plasticity with regions of urothelial carcinoma adjacent to or admixed with regions of divergent histomorphology, most commonly squamous differentiation. To define the biologic basis for and clinical significance of this morphologic heterogeneity, here we perform integrated genomic analyses of mixed histology bladder cancers with separable regions of urothelial and squamous differentiation. We find that squamous differentiation is a marker of intratumoral genomic and immunologic heterogeneity in patients with bladder cancer and a biomarker of intrinsic immunotherapy resistance. Phylogenetic analysis confirms that in all cases the urothelial and squamous regions are derived from a common shared precursor. Despite the presence of marked genomic heterogeneity between co-existent urothelial and squamous differentiated regions, no recurrent genomic alteration exclusive to the urothelial or squamous morphologies is identified. Rather, lineage plasticity in bladder cancers with squamous differentiation is associated with loss of expression of FOXA1, GATA3, and PPARG, transcription factors critical for maintenance of urothelial cell identity. Of clinical significance, lineage plasticity and PD-L1 expression is coordinately dysregulated via FOXA1, with patients exhibiting morphologic heterogeneity pre-treatment significantly less likely to respond to immune checkpoint inhibitors.

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Multi Lineage Heterogeneity and Plasticity in Urothelial Carcinoma of the Bladder

Project description:Single cell transcriptome analyses of mouse and human model systems of bladder cancer

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Lineage Plasticity in Cancer Progression and Treatment.

Project description:Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticity by changing their identity, either by dedifferentiation to a progenitor-like state or by transdifferentiation to an alternative differentiated cell type. Such cellular plasticity can be triggered by physiological or oncogenic stress, or it can be experimentally induced through cellular reprogramming. Notably, physiological stresses that promote plasticity, such as severe tissue damage, inflammation, or senescence, also represent hallmarks of cancer. Furthermore, key drivers of cellular plasticity include major oncogenic and tumor suppressor pathways and can be exacerbated by drug treatment. Thus, plasticity may help cancer cells evade detection and treatment. We propose that cancer can be considered as a disease of excess plasticity, a notion that has important implications for intervention and treatment.

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MUC1-C Drives Lineage Plasticity in Progression to Neuroendocrine Prostate Cancer

Project description:Neuroendocrine prostate cancer (NEPC) is a highly aggressive malignancy of increasing prevalence with an unmet need for targeted therapeutic approaches. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC; however, there is no known role for MUC1-C in driving lineage plasticity to these advanced PC phenotypes. The present studies demonstrate that upregulation of MUC1-C in androgen-independent (AI) PC cells suppresses androgen receptor (AR) axis signaling and induces the neural BRN2 transcription factor by a previously unrecognized MYC-mediated mechanism. MUC1-C activates the BRN2 pathway in association with induction of MYCN, EZH2 and NE differentiation markers (ASCL1, AURKA and SYP), which are linked to NEPC progression. We also show that MUC1-C suppresses the p53 pathway, induces the Yamanaka pluripotency factors (OCT4, SOX2, KLF4 and MYC) and drives stemness. Of potential clinical relevance, targeting MUC1-C decreases PC self-renewal capacity and tumorigenicity, supporting the treatment of CRPC and NEPC with agents directed against this oncoprotein. These findings and the demonstration that MUC1-C is upregulated and associated with suppression of AR signaling, and increases in BRN2 expression and the NEPC score in PC tissues highlight the unanticipated importance of MUC1-C as a master effector of lineage plasticity in progression to advanced PC with NE features.

2019-12-02 | GSE139335 | GEO

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