Ontology highlight
ABSTRACT:
SUBMITTER: Janjuha S
PROVIDER: S-EPMC5943033 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Janjuha Sharan S Singh Sumeet Pal SP Tsakmaki Anastasia A Mousavy Gharavy S Neda SN Murawala Priyanka P Konantz Judith J Birke Sarah S Hodson David J DJ Rutter Guy A GA Bewick Gavin A GA Ninov Nikolay N
eLife 20180406
The pancreatic islet, a cellular community harboring the insulin-producing beta-cells, is known to undergo age-related alterations. However, only a handful of signals associated with aging have been identified. By comparing beta-cells from younger and older zebrafish, here we show that the aging islets exhibit signs of chronic inflammation. These include recruitment of <i>tnfα</i>-expressing macrophages and the activation of NF-kB signaling in beta-cells. Using a transgenic reporter, we show tha ...[more]