Ontology highlight
ABSTRACT:
SUBMITTER: Inoue N
PROVIDER: S-EPMC5943276 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Inoue Nobuko N Nishizumi Hirofumi H Naritsuka Hiromi H Kiyonari Hiroshi H Sakano Hitoshi H
Nature communications 20180509 1
In mammals, neural circuits are formed based on a genetic program and further refined by neuronal activity during the neonatal period. We report that in the mouse olfactory system, the glomerular map is not merely refined but newly connected to second-order neurons by odorant-receptor-derived neuronal activity. Here, we analyzed a pair of molecules, Sema7A, expressed in olfactory sensory neurons (OSNs) in an activity-dependent manner, and PlxnC1, localized to dendrites of mitral/tufted (M/T) cel ...[more]