Ontology highlight
ABSTRACT:
SUBMITTER: Tsai PI
PROVIDER: S-EPMC3491500 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Tsai Pei-I PI Wang Manyu M Kao Hsiu-Hua HH Cheng Ying-Ju YJ Lin Yu-Jing YJ Chen Ruey-Hwa RH Chien Cheng-Ting CT
Proceedings of the National Academy of Sciences of the United States of America 20121010 43
Retrograde signals induced by synaptic activities are derived from postsynaptic cells to potentiate presynaptic properties, such as cytoskeletal dynamics, gene expression, and synaptic growth. However, it is not known whether activity-dependent retrograde signals can also depotentiate synaptic properties. Here we report that laminin A (LanA) functions as a retrograde signal to suppress synapse growth at Drosophila neuromuscular junctions (NMJs). The presynaptic integrin pathway consists of the i ...[more]