Ontology highlight
ABSTRACT:
SUBMITTER: Cui X
PROVIDER: S-EPMC5943350 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cui Xiaofang X Chang Linmo L Li Youwei Y Lv Qianrui Q Wang Fei F Lin Yaxian Y Li Weiyang W Meade Jonathan D JD Walden Jamie C JC Liang Peng P
Scientific reports 20180509 1
Tumor necrosis factor is a major pro-inflammatory cytokine which triggers various physiological consequences by binding to and trimerizing its receptors, and has been the single most sought-after drug target for intervening autoimmune diseases such as rheumatoid arthritis and psoriasis. However, current TNF-α blockers, including soluble receptor-Fc fusion and therapeutic antibodies, are all dimeric in structure, whereas their target TNF-α itself is homotrimeric in nature. Here we describe the de ...[more]