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Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model.


ABSTRACT: Managing endovascular thrombectomy (ET) in diabetic ischemic stroke (IS) with novel anticoagulants is challenging due to putative risk of intracerebral hemorrhage. The study evaluates increased hemorrhagic transformation (HT) risk in Rivaroxaban-treated diabetic rats post ET. Diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of 60?mg/kg streptozotocin. After 4-weeks, rats were pretreated orally with 30?mg/kg Rivaroxaban/saline; prothrombin time was monitored. IS and ET was induced after 1?h, by thread-induced transient middle cerebral artery occlusion (tMCAO) that mimicked mechanical ET for proximal MCA occlusion at 60?min. After 24?h reperfusion, infarct volumes, HT, blood-brain barrier (BBB) permeability, tight junction at peri-ischemic lesion and matrix metalloproteinase-9 (MMP-9) activity was measured. Diabetic rats seemed to exhibit increased infarct volume and HT at 24?h after ET than normal rats. Infarct volumes and functional outcomes did not differ between Rivaroxaban and diabetic control groups. A significant increase in HT volumes and BBB permeability under Rivaroxaban treatment was not detected. Compared to diabetic control group, neither the occludin expression was remarkably lower in the Rivaroxaban group nor the MMP-9 activity was higher. Together, Rivaroxaban does not increase HT after ET in diabetic rats with proximal MCA occlusion, since Rivaroxaban has fewer effects on post-ischemic BBB permeability.

SUBMITTER: Liu FD 

PROVIDER: S-EPMC5943582 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model.

Liu Feng-Di FD   Zhao Rong R   Feng Xiao-Yan XY   Shi Yan-Hui YH   Wu Yi-Lan YL   Shen Xiao-Lei XL   Li Ge-Fei GF   Liu Yi-Sheng YS   Zhao Ying Y   He Xin-Wei XW   Yin Jia-Wen JW   Zhuang Mei-Ting MT   Zhao Bing-Qiao BQ   Liu Jian-Ren JR  

Scientific reports 20180509 1


Managing endovascular thrombectomy (ET) in diabetic ischemic stroke (IS) with novel anticoagulants is challenging due to putative risk of intracerebral hemorrhage. The study evaluates increased hemorrhagic transformation (HT) risk in Rivaroxaban-treated diabetic rats post ET. Diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of 60 mg/kg streptozotocin. After 4-weeks, rats were pretreated orally with 30 mg/kg Rivaroxaban/saline; prothrombin time was monitored. IS and E  ...[more]

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