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Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer.


ABSTRACT: BACKGROUND:Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria. MATERIALS AND METHODS:We retrospectively reviewed medical records of 546 low-risk PC patients who had undergone RP. Low-risk PC was defined as PC with clinical T1-T2a, Gleason score???6, and PSA levels ?4.5 ng/mL and number of positive cores >?2 in low-risk PC were significantly associated with APFs, and suggested as cut-off values for predicting APFs. CONCLUSIONS:PSA?>?4.5 ng/mL and number of positive cores >?2 in low-risk PC were associated with presence of APFs and patients with such records should be considered carefully to provide active surveillance.

SUBMITTER: Park JW 

PROVIDER: S-EPMC5944136 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer.

Park Jae Won JW   Koh Dong Hoon DH   Jang Won Sik WS   Cho Kang Su KS   Ham Won Sik WS   Rha Koon Ho KH   Hong Sung Joon SJ   Choi Young Deuk YD  

BMC cancer 20180509 1


<h4>Background</h4>Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria.<h4>Materials and methods</h4>We retrospectively reviewed medical records o  ...[more]

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