Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms.
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ABSTRACT:
SUBMITTER: Cobbaut M
PROVIDER: S-EPMC5944262 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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Function and Regulation of Protein Kinase D in Oxidative Stress: A Tale of Isoforms.
Cobbaut Mathias M Van Lint Johan J
Oxidative medicine and cellular longevity 20180426
Oxidative stress is a condition that arises when cells are faced with levels of reactive oxygen species (ROS) that destabilize the homeostatic redox balance. High levels of ROS can cause damage to macromolecules including DNA, lipids, and proteins, eventually resulting in cell death. Moderate levels of ROS however serve as signaling molecules that can drive and potentiate several cellular phenotypes. Increased levels of ROS are associated with a number of diseases including neurological disorder ...[more]
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