Ontology highlight
ABSTRACT:
SUBMITTER: Truillet C
PROVIDER: S-EPMC5945515 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Truillet Charles C Parker Matthew F L MFL Huynh Loc T LT Wei Junnian J Jami Khaled M KM Wang Yung-Hua YH Shen Yuqin S YS Sriram Renuka R Wilson David M DM Kurhanewicz John J Evans Michael J MJ
Oncotarget 20180417 29
The glucocorticoid receptor (GR) is an emerging drug target for several common and deadly solid tumors like breast and prostate cancer, and clinical trials studying the antitumor effects of GR antagonists are beginning. Since GR expression can be variable in tumor cells, and virtually all normal mammalian tissues express some GR, we hypothesized that an imaging tool capable of detecting GR positive tumors and/or measuring GR occupancy by drug in tumor and normal tissues could improve the precisi ...[more]