Ontology highlight
ABSTRACT:
SUBMITTER: Caja L
PROVIDER: S-EPMC5945579 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Caja Laia L Tzavlaki Kalliopi K Dadras Mahsa S MS Tan E-Jean EJ Hatem Gad G Maturi Naga P NP Morén Anita A Wik Lotta L Watanabe Yukihide Y Savary Katia K Kamali-Moghaddan Masood M Uhrbom Lene L Heldin Carl-Henrik CH Moustakas Aristidis A
Oncogene 20180216 19
Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor β (TGFβ) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in ...[more]