Ontology highlight
ABSTRACT:
SUBMITTER: Wioland H
PROVIDER: S-EPMC7857426 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Wioland Hugo H Frémont Stéphane S Guichard Bérengère B Echard Arnaud A Jégou Antoine A Romet-Lemonne Guillaume G
EMBO reports 20210104 2
Proteins of the ADF/cofilin family play a central role in the disassembly of actin filaments, and their activity must be tightly regulated in cells. Recently, the oxidation of actin filaments by the enzyme MICAL1 was found to amplify the severing action of cofilin through unclear mechanisms. Using single filament experiments in vitro, we found that actin filament oxidation by MICAL1 increases, by several orders of magnitude, both cofilin binding and severing rates, explaining the dramatic synerg ...[more]