Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.

ABSTRACT: Interferon gamma (IFN-?) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell-cell interactions between monocytes and T cells regulate IFN-? production. In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants. In vitro, RSV increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited IFN-? production by adult CD4+ T cells. In contrast, IFN-? production by RSV in newborns was not affected by Siglec-1. The ligand for Siglec-1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec-1 reduces IFN-? release by adult T cells possibly by binding to the highly expressed CD43. The Siglec-1-dependent inhibition of IFN-? in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.

SUBMITTER: Jans J 

PROVIDER: S-EPMC5947594 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature