Ontology highlight
ABSTRACT:
SUBMITTER: Abd Hamid M
PROVIDER: S-EPMC7066077 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Abd Hamid Megat M Yao Xuan X Waugh Craig C Rosendo-Machado Samara S Li Chris C Rostron Timothy T Frankland John J Peng Yanchun Y Dong Tao T
Frontiers in immunology 20200305
Interferon gamma (IFNγ) supports effector responses of CD8<sup>+</sup> cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship between IFNγ production and the 5'methylcytosine-guanine (CpG) dinucleotide methylation of the IFNγ promoter using bisulfite treatment has shown that IFNγ<sup>-</sup> CTL clones accumulates C ...[more]