Ontology highlight
ABSTRACT:
SUBMITTER: Yun S
PROVIDER: S-EPMC5948139 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yun Sanghee S Reynolds Ryan P RP Petrof Iraklis I White Alicia A Rivera Phillip D PD Segev Amir A Gibson Adam D AD Suarez Maiko M DeSalle Matthew J MJ Ito Naoki N Mukherjee Shibani S Richardson Devon R DR Kang Catherine E CE Ahrens-Nicklas Rebecca C RC Soler Ivan I Chetkovich Dane M DM Kourrich Saïd S Coulter Douglas A DA Eisch Amelia J AJ
Nature medicine 20180416 5
Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry, such as the entorhinal cortex (Ent), is antidepressive, although Ent stimulation improves learning and memory in mice and humans. Here we show that molecular targeting (Ent-specific knockdown of a psychosocial stress-induced protein) and chemogenetic stim ...[more]