Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Ruiz A
PROVIDER: S-EPMC8285088 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Fernández-Ruiz Antonio A Oliva Azahara A Soula Marisol M Rocha-Almeida Florbela F Nagy Gergo A GA Martin-Vazquez Gonzalo G Buzsáki György G
Science (New York, N.Y.) 20210401 6537
Gamma oscillations are thought to coordinate the spike timing of functionally specialized neuronal ensembles across brain regions. To test this hypothesis, we optogenetically perturbed gamma spike timing in the rat medial (MEC) and lateral (LEC) entorhinal cortices and found impairments in spatial and object learning tasks, respectively. MEC and LEC were synchronized with the hippocampal dentate gyrus through high- and low-gamma-frequency rhythms, respectively, and engaged either granule cells o ...[more]