Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC5951830 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lin Huan H Miyauchi Kenjyo K Harada Tai T Okita Ryo R Takeshita Eri E Komaki Hirofumi H Fujioka Kaoru K Yagasaki Hideki H Goto Yu-Ichi YI Yanaka Kaori K Nakagawa Shinichi S Sakaguchi Yuriko Y Suzuki Tsutomu T
Nature communications 20180514 1
It has been generally thought that tRNA modifications are stable and static, and their frequencies are rarely regulated. N<sup>6</sup>-threonylcarbamoyladenosine (t<sup>6</sup>A) occurs at position 37 of five mitochondrial (mt-)tRNA species. We show that YRDC and OSGEPL1 are responsible for t<sup>6</sup>A37 formation, utilizing L-threonine, ATP, and CO<sub>2</sub>/bicarbonate as substrates. OSGEPL1-knockout cells exhibit respiratory defects and reduced mitochondrial translation. We find low leve ...[more]