Ontology highlight
ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC5953954 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Song Mengjia M Chen Xinfeng X Wang Liping L Zhang Yi Y
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 20180401 2
Programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) blockade has shown promising effects in cancer immunotherapy. Removing the so-called " brakes" on T cell immune responses by blocking the PD-1/PD-L1 check point should boost anti-tumor immunity and provide durable tumor regression for cancer patients. However, 30%-60% of patients show no response to PD-1/PD-L1 blockade. Thus, it is urgent to explore the underlying resistance mechanisms to improve sensitivity to anti-PD-1/PD-L1 ...[more]