Ontology highlight
ABSTRACT:
SUBMITTER: Harris BRE
PROVIDER: S-EPMC5954198 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Harris Benjamin R E BRE Wang Defeng D Zhang Ye Y Ferrari Marina M Okon Aniekan A Cleary Margot P MP Wagner Carston R CR Yang Da-Qing DQ
Molecular and cellular biology 20180430 10
The p53 tumor suppressor plays a critical role in protecting normal cells from malignant transformation. Development of small molecules to reactivate p53 in cancer cells has been an area of intense research. We previously identified an internal ribosomal entry site (IRES) within the 5' untranslated region of p53 mRNA that mediates translation of the p53 mRNA independent of cap-dependent translation. Our results also show that in response to DNA damage, cells switch from cap-dependent translation ...[more]