Ontology highlight
ABSTRACT:
SUBMITTER: Tsuchiya N
PROVIDER: S-EPMC7425979 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Tsuchiya Naoto N Izumiya Masashi M Ogata-Kawata Hiroko H Okamoto Koji K Fujiwara Yuko Y Nakai Makiko M Okabe Atsushi A Schetter Aaron J AJ Bowman Elise D ED Midorikawa Yutaka Y Sugiyama Yasuyuki Y Aburatani Hiroyuki H Harris Curtis C CC Nakagama Hitoshi H
Cancer research 20110512 13
Selective activation of p53 target genes in response to various cellular stresses is a critical step in determining the ability to induce cell-cycle arrest or apoptosis. Here we report the identification of the microRNA miR-22 as a p53 target gene that selectively determines the induction of p53-dependent apoptosis by repressing p21. Combinatorial analyses of the AGO2 immunocomplex and gene expression profiles identified p21 as a direct target of miR-22. Induction of p21 was inhibited by miR-22 ...[more]