Ontology highlight
ABSTRACT:
SUBMITTER: Decaudin D
PROVIDER: S-EPMC5955168 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Decaudin Didier D El Botty Rania R Diallo Béré B Massonnet Gerald G Fleury Justine J Naguez Adnan A Raymondie Chloé C Davies Emma E Smith Aaron A Wilson Joanne J Howes Colin C Smith Paul D PD Cassoux Nathalie N Piperno-Neumann Sophie S Roman-Roman Sergio S Némati Fariba F
Oncotarget 20180424 31
The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated the potential of drug combinations to increase the efficacy of the MEK inhibitor selumetinib (AZD6244, ARRY-142886), in UM cell lines and Patient-Derived Xenografts. We first evaluated the combination ...[more]