Ontology highlight
ABSTRACT:
SUBMITTER: Tomasi ML
PROVIDER: S-EPMC5956242 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Tomasi Maria Lauda ML Ramani Komal K Ryoo Minjung M Cossu Carla C Floris Andrea A Murray Ben J BJ Iglesias-Ara Ainhoa A Spissu Ylenia Y Mavila Nirmala N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180118 6
Alcohol acts through numerous pathways leading to alcoholic liver disease (ALD). Cytochrome P450 (CYP2E1), an ethanol-inducible enzyme, metabolizes ethanol-producing toxic reactive oxygen species (ROS) and is regulated at the posttranslational level. Small ubiquitin-like modifier (SUMO)ylation is a posttranslational modification that involves the addition of SUMOs, which modulate protein stability, activity, and localization. We demonstrated that ubiquitin-conjugation enzyme 9, the SUMO-conjugat ...[more]