Ontology highlight
ABSTRACT:
SUBMITTER: Paul TJ
PROVIDER: S-EPMC5956519 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Paul Thomas J TJ Hoffmann Zachary Z Wang Congzhou C Shanmugasundaram Maruda M DeJoannis Jason J Shekhtman Alexander A Lednev Igor K IK Yadavalli Vamsi K VK Prabhakar Rajeev R
The journal of physical chemistry letters 20160708 14
In this combined experimental (deep ultraviolet resonance Raman (DUVRR) spectroscopy and atomic force microscopy (AFM)) and theoretical (molecular dynamics (MD) simulations and stress-strain (SS)) study, the structural and mechanical properties of amyloid beta (Aβ40) fibrils have been investigated. The DUVRR spectroscopy and AFM experiments confirmed the formation of linear, unbranched and β-sheet rich fibrils. The fibrils (Aβ40)n, formed using n monomers, were equilibrated using all-atom MD sim ...[more]