A Macrophage Colony-Stimulating-Factor-Producing ?? T Cell Subset Prevents Malarial Parasitemic Recurrence.

ABSTRACT: Despite evidence that ?? T cells play an important role during malaria, their precise role remains unclear. During murine malaria induced by Plasmodium chabaudi infection and in human P. falciparum infection, we found that ?? T cells expanded rapidly after resolution of acute parasitemia, in contrast to ?? T cells that expanded at the acute stage and then declined. Single-cell sequencing showed that TRAV15N-1 (V?6.3) ?? T cells were clonally expanded in mice and had convergent complementarity-determining region 3 sequences. These ?? T cells expressed specific cytokines, M-CSF, CCL5, CCL3, which are known to act on myeloid cells, indicating that this ?? T cell subset might have distinct functions. Both ?? T cells and M-CSF were necessary for preventing parasitemic recurrence. These findings point to an M-CSF-producing ?? T cell subset that fulfills a specialized protective role in the later stage of malaria infection when ?? T cells have declined.

SUBMITTER: Mamedov MR 

PROVIDER: S-EPMC5956914 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature