Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC5957489 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Immunity 20170314 3
Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol-25-hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25-hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Synthetic 25HC addi ...[more]