Ontology highlight
ABSTRACT:
SUBMITTER: Gold ES
PROVIDER: S-EPMC3328364 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Gold Elizabeth S ES Ramsey Stephen A SA Sartain Mark J MJ Selinummi Jyrki J Podolsky Irina I Rodriguez David J DJ Moritz Robert L RL Aderem Alan A
The Journal of experimental medicine 20120402 4
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. We demonstrate that macrophage lipid body formation can be induced by modified lipoproteins or by inflammatory Toll-like receptor agonists. We used an unbiased approach to study the overlap in these pathways to identify regulators that control foam cell formation and atherogenesis. An analysis method integrating epigenomic and transcriptomic datasets with a transc ...[more]