Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.
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ABSTRACT:
SUBMITTER: Lomberk G
PROVIDER: S-EPMC5958058 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.
Lomberk Gwen G Blum Yuna Y Nicolle Rémy R Nair Asha A Gaonkar Krutika Satish KS Marisa Laetitia L Mathison Angela A Sun Zhifu Z Yan Huihuang H Elarouci Nabila N Armenoult Lucile L Ayadi Mira M Ordog Tamas T Lee Jeong-Heon JH Oliver Gavin G Klee Eric E Moutardier Vincent V Gayet Odile O Bian Benjamin B Duconseil Pauline P Gilabert Marine M Bigonnet Martin M Garcia Stephane S Turrini Olivier O Delpero Jean-Robert JR Giovannini Marc M Grandval Philippe P Gasmi Mohamed M Secq Veronique V De Reyniès Aurélien A Dusetti Nelson N Iovanna Juan J Urrutia Raul R
Nature communications 20180517 1
Recent studies have offered ample insight into genome-wide expression patterns to define pancreatic ductal adenocarcinoma (PDAC) subtypes, although there remains a lack of knowledge regarding the underlying epigenomics of PDAC. Here we perform multi-parametric integrative analyses of chromatin immunoprecipitation-sequencing (ChIP-seq) on multiple histone modifications, RNA-sequencing (RNA-seq), and DNA methylation to define epigenomic landscapes for PDAC subtypes, which can predict their relativ ...[more]
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