Ontology highlight
ABSTRACT:
SUBMITTER: Dai X
PROVIDER: S-EPMC5959011 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180405 6384
Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between sites of infection and neuronal cell bodies. Here we report cryo-electron microscopy structures of the HSV-1 capsid with CATC up to 3.5-angstrom resolution and atomic models of multiple conformers of capsid proteins VP5, VP19c, VP23, and VP26 and tegument proteins pUL17, pUL25, and pUL36. Crowning every capsid vertex are five copies of heterop ...[more]