Ontology highlight
ABSTRACT:
SUBMITTER: Mohr JP
PROVIDER: S-EPMC5959040 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mohr Jared P JP Perumalla Poorna P Chavez Juan D JD Eng Jimmy K JK Bruce James E JE
Analytical chemistry 20180427 10
Chemical cross-linking combined with mass spectrometry provides a method to study protein structures and interactions. The introduction of cleavable bonds in a cross-linker provides an avenue to decouple released peptide masses from their precursor species, greatly simplifying the downstream search, allowing for whole proteome investigations to be performed. Typically, these experiments have been challenging to carry out, often utilizing nonstandard methods to fully identify cross-linked peptide ...[more]