Ontology highlight
ABSTRACT:
SUBMITTER: Labed SA
PROVIDER: S-EPMC5959051 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Labed Sid Ahmed SA Wani Khursheed A KA Jagadeesan Sakthimala S Hakkim Abdul A Najibi Mehran M Irazoqui Javier Elbio JE
Immunity 20180501 5
Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense against infection and to microbiota homeostasis. Understanding the mechanisms that regulate such expression is necessary for understanding immune homeostasis and inflammatory disease and for developing safe and effective therapies. We used Caenorhabditis elegans in a preclinical approach to discover mechanisms of antimicrobial gene expression control in the intestinal epithelium. We found an unexpected role ...[more]